Bedaquiline is a crucial antibiotic for treating TB, particularly MDR-TB. It significantly improves treatment outcomes by reducing mortality and shortening therapy duration compared to older, less effective, often injectable, regimens. A long-acting formulation of bedaquiline could be useful as a new modality to increase adherence in the treatment of latent TB infection (LTBI, also known as TB preventive treatment, TPT), which is recommended by WHO for people living with HIV, household contacts of people with TB, and other risk groups. Bedaquiline long-acting is in phase I and data on safety and efficacy are still immature. Although the compound patent expired in 2023, Janssen owns several patents in LMICs on long-acting formulations of bedaquiline expiring between 2038 and 2041.